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New role of adenosine in the regulation of REM sleep discovered

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The regulation and function of sleep is one of the biggest black boxes of today’s brain science. A new paper published online on August 2 in the journal “Brain Structure & Function” finds that rapid eye movement (REM) sleep is suppressed by adenosine acting on a specific subtype of adenosine receptors, the A2A receptors, in the olfactory bulb. The study was conducted by researchers at Fudan University’s School of Basic Medical Sciences in the Department of Pharmacology and the University of Tsukuba’s International Institute for Integrative Sleep Medicine (WPI-IIIS).

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