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Check out these newsworthy studies from the August 31, 2016, issue of JNeurosci. Damage to the central nervous system — the brain and spinal cord — tends to be permanent. Some evidence shows axons can be encouraged to regrow, but it’s unclear whether these approaches also support remyelination of nerve fibers or re-establish the clusters of ion channels needed for signal conduction. In this study, researchers find deleting the tumor suppressor gene PTEN and stimulating an immune response dramatically enhanced axon growth, remyelination, and ion channel clustering. The results are the first to demonstrate that regenerated nerves in the central nervous system can restore myelin and ion channel clustering necessary for normal signaling.
Check out these newsworthy studies from the August 31, 2016, issue of JNeurosci. Damage to the central nervous system — the brain and spinal cord — tends to be permanent. Some evidence shows axons can be encouraged to regrow, but it’s unclear whether these approaches also support remyelination of nerve fibers or re-establish the clusters of ion channels needed for signal conduction. In this study, researchers find deleting the tumor suppressor gene PTEN and stimulating an immune response dramatically enhanced axon growth, remyelination, and ion channel clustering. The results are the first to demonstrate that regenerated nerves in the central nervous system can restore myelin and ion channel clustering necessary for normal signaling.