People with major depressive disorder (MDD) feel more negative emotion when remembering painful experiences than people without the disorder, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. The study reports that people with MDD were able to control the negative emotions about as well as people unaffected by MDD, but used somewhat different brain circuits to do so. The findings identify brain differences in MDD related to processing of autobiographical memories, the memories of the events and knowledge of one's life, that help us form our self-identity and guide our interactions with the world.
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